Aggregation-Clearance Control Twin
Open frontier — a grand hard problem, not yet benchmarked.
This is a framing page: the governing equation and what "solved" would mean. There are no verified results or solutions yet — unlike PWM's mature, reproduced computational-imaging benchmarks. Help define it: propose a sharper governing equation, a digital twin, or the first real benchmark — and earn PWM.
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Improve L2-905 — submit with or without uploading. Accepted submissions earn the 1/16 modify share of A(t).
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Prompt — copy into your LLM
You are helping me submit a MODIFICATION of L2-905 (Aggregation-Clearance Control Twin) to the PWM Protocol — a Digital Twin (L2) artifact. I will paste a Markdown template (or the current L2-905.md). 1. Rewrite the Markdown so the science is correct and clearly explained for my change. 2. Regenerate the sibling L2-905.json so EVERY field matches the Markdown. 3. Keep the schema in the "File Mapping" footer at the bottom of the MD. 4. Keep the parent reference unchanged unless I ask otherwise. Rules: the Markdown is the source of truth; use SI units; do NOT invent benchmark scores. Output each file in its own fenced code block tagged with the filename. Here is my template: [PASTE THE .md HERE]
⚙ Forward Model
derived from principle L1-905Nucleation–elongation aggregation master equation (Knowles): aggregate mass M(t) from primary/secondary nucleation and elongation rate constants; clearance by proteostasis network.