# 📐  L2 Digital Twin — Partial-Reprogramming Dose–Response Twin

**ID:** `L2-901` · **Status:** ⊙ Testnet (genesis catalog)
**Parents:** ⬆ Principle [`L1-901`](/artifact/l1/L1-901)

> **🎯 Tolerance (ε):** expression
> **⚖ Difficulty score:** 0.9 · **Delta tier:** 50

---

## 1. Domain Ω

**Type:** `range`

| Parameter | Unit | Range |
|---|---|---|
| Osk dose | — | 0.0 – 1.0 |
| Cell type | — | fibroblast|neuron|hepatocyte |
| Induction days | — | 1 – 21 |

## 2. Tolerance (ε)

**Type:** `fn`

```
≤ 2 yr error on restored DNAm age, identity markers preserved (no dedifferentiation)
```

## 3. Difficulty

| Property | Value |
|---|---|
| Difficulty score | 0.9 |
| Delta tier | 50 |

## 4. Fingerprint

`2147aa6e88664f7faabd8686c86d2e87501f13d47367c471208441416e96ad17`

---

## File Mapping

This bundle consists of: `L2-901.md`, `L2-901.json`.

| File | Role | How to regenerate |
|------|------|-------------------|
| `L2-901.md` | Source of truth — edit this | Human or LLM |
| `L2-901.json` | Structured metadata for the registry | LLM regenerates from the sections above |

**Prompt for your LLM after editing this Markdown:**

> Read the attached Markdown. Regenerate the sibling `.json` so every field matches.
> Preserve the schema documented in the rows above.
> Output each file in its own fenced code block tagged with the filename.
> Output only the JSON object.

_This Markdown was auto-synthesized from the catalog row for `L2-901`._
_Edit it, regenerate the JSON, and submit at [/submit](/submit) to claim the artifact._