# ⚛  L1 Principle — Proteostasis Collapse & Neurodegeneration

**ID:** `L1-905` · **Status:** ⊙ Testnet (genesis catalog)

> **🌐 Domain:** Neurodegeneration — *Protein Aggregation*

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## 🧠 1. Introduction

**Proteostasis Collapse & Neurodegeneration** is a **inverse problem**, within the **Protein Aggregation** sub-domain of **Neurodegeneration**.

## ⚙ 2. Forward Model

```
Nucleation–elongation aggregation master equation (Knowles): aggregate mass M(t) from primary/secondary nucleation and elongation rate constants; clearance by proteostasis network.
```

## 🔬 3. Physics Fingerprint

| Property | Value |
|---|---|
| Domain | Neurodegeneration |
| Sub domain | Protein Aggregation |

## 📡 4. Measurement Model

| Metric | Value |
|---|---|
| Metric | load_reduction |

## ⚖ 6. Hardness Function

Hardness scales as **`grand_challenge`** on **load_reduction**.

## 💾 7. Reference Dataset

- **CSF amyloid/tau longitudinal (ADNI-like)** · weight 0.5 · IPFS _(not pinned yet)_
- **In-vitro aggregation kinetics panel** · weight 0.3 · IPFS _(not pinned yet)_
- **Proteostasis-network perturbation screen** · weight 0.2 · IPFS _(not pinned yet)_

**Staked PWM:** 5000.0

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## File Mapping

This bundle consists of: `L1-905.md`, `L1-905.json`.

| File | Role | How to regenerate |
|------|------|-------------------|
| `L1-905.md` | Source of truth — edit this | Human or LLM |
| `L1-905.json` | Structured metadata for the registry | LLM regenerates from the sections above |

**Prompt for your LLM after editing this Markdown:**

> Read the attached Markdown. Regenerate the sibling `.json` so every field matches.
> Preserve the schema documented in the rows above.
> Output each file in its own fenced code block tagged with the filename.
> Output only the JSON object.

_This Markdown was auto-synthesized from the catalog row for `L1-905`._
_Edit it, regenerate the JSON, and submit at [/submit](/submit) to claim the artifact._