# ⚛  L1 Principle — Epigenetic Reprogramming & Reverse Aging

**ID:** `L1-901` · **Status:** ⊙ Testnet (genesis catalog)

> **🌐 Domain:** Aging Biology — *Epigenetic Reprogramming*

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## 🧠 1. Introduction

**Epigenetic Reprogramming & Reverse Aging** is a **inverse problem**, within the **Epigenetic Reprogramming** sub-domain of **Aging Biology**.

## ⚙ 2. Forward Model

```
Information-theoretic aging: biological age A(t) accumulates as epigenetic noise; transient OSK reprogramming u(t) drives dA/dt = k_dmg − k_rep·u(t), read out by a DNA-methylation clock.
```

## 🔬 3. Physics Fingerprint

| Property | Value |
|---|---|
| Domain | Aging Biology |
| Sub domain | Epigenetic Reprogramming |

## 📡 4. Measurement Model

| Metric | Value |
|---|---|
| Metric | years_reversed |

## ⚖ 6. Hardness Function

Hardness scales as **`grand_challenge`** on **years_reversed**.

## 💾 7. Reference Dataset

- **Multi-tissue DNAm reprogramming atlas** · weight 0.5 · IPFS _(not pinned yet)_
- **Horvath pan-tissue clock corpus** · weight 0.3 · IPFS _(not pinned yet)_
- **OSK transient-induction time course** · weight 0.2 · IPFS _(not pinned yet)_

**Staked PWM:** 5000.0

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## File Mapping

This bundle consists of: `L1-901.md`, `L1-901.json`.

| File | Role | How to regenerate |
|------|------|-------------------|
| `L1-901.md` | Source of truth — edit this | Human or LLM |
| `L1-901.json` | Structured metadata for the registry | LLM regenerates from the sections above |

**Prompt for your LLM after editing this Markdown:**

> Read the attached Markdown. Regenerate the sibling `.json` so every field matches.
> Preserve the schema documented in the rows above.
> Output each file in its own fenced code block tagged with the filename.
> Output only the JSON object.

_This Markdown was auto-synthesized from the catalog row for `L1-901`._
_Edit it, regenerate the JSON, and submit at [/submit](/submit) to claim the artifact._